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Contraindicated (1)pentobarbital will lessen the extent or outcome of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with powerful CYP3A4 inducers may end up in diminished serum concentrations and lack of antimalarial efficacyObserve Carefully (2)pentobarbital will lower the level or effec